Work Package 3 – Towards Continuous
This WP will translate conventional batch resolution processes to continuous configurations. The approach consists of developing general design rules for continuous processes (T3.1), developing continuous configurations of crystallization-based chiral synthesis (T3.2) and developing optimized continuous versions of preferential crystallization and Viedma Ripening (T3.3). The 3 tasks are integrated by the ESR’s joint construction and application of process models for all types of continuous resolution.
Work Package 4 – Hybrid Resolution
This WP will focus on hybrid resolution processes combining racemization and crystallization. The first task is to enlarge the application area of crystallization-enabled chiral synthesis (T4.1). Additionally, the crystallization processes relevant in Viedma Ripening and Second Order Asymmetric Transformation (SOAT) will be optimized (T4.2). The third task is to extend the application area of Viedma Ripening and SOAT by increasing the library of racemization reactions to include new chiral centers (T4.3). Through secondments and network events the ESR project results will be exchanged and applied throughout the different tasks.
Work Package 5 – Enabling Resolution
The WP focusses on enabling resolution through 3 approaches. To enable resolution, a conglomerate is preferred (T5.1), crystallization behaviour should be known (T5.2) and it should be possible to monitor the resolution process (T5.3).